Longevity is no longer just about adding years to life — it’s about adding life to those years. In today’s wellness-focused culture, longevity has emerged as the new gold standard for healthier, smarter aging. The goal is not merely to extend lifespan, but to expand healthspan — the number of years one remains active, mentally sharp, and independent, free from the burden of chronic disease and age-related decline.
This platform is built on a commitment to advancing lifestyle strategies that support lasting vitality. It was founded on the belief that with the right information and tools, anyone can take charge of their well-being. We now live in an era with unprecedented access to innovations that empower prevention and early intervention. From cutting-edge diagnostic imaging and biomarker testing to personalized nutrition, wearable health tech, and functional medicine, the tools for transformation are here. Today’s approach to aging focuses on proactive care — targeting gut health, hormonal balance, brain optimization, and stress resilience. Nutrient-dense, anti-inflammatory eating, individualized plans rooted in DNA, and real-time feedback from tech-enabled devices are helping more people stay ahead of illness and thrive through every stage of life.
This site invites readers to explore evidence-based insights and solutions designed to help them feel youthful, energized, and resilient — redefining what it means to grow older with purpose and strength.
Dr. Angela Mazza, DO, ABAARM, FAAMFM, ECNU, CDE, is a board-certified endocrinologist and the visionary founder of the Metabolic Center for Wellness in Oviedo, Florida. With more than two decades of clinical and academic experience, she is nationally recognized for her integrative and functional approach to endocrine disorders, particularly thyroid health, adrenal dysfunction, metabolic disease, and longevity medicine.
Dr. Mazza holds multiple fellowships in Anti-Aging and Functional Metabolic Medicine through A4M and is certified in Endocrine Neck Ultrasound and Diabetes Education. A prolific speaker and educator, she regularly presents at global medical conferences, including A4M, IFM, and the Endocrine Society. Her research and publications span topics such as autoimmune thyroiditis, metabolic aging, and hormone balance. She is the host of the podcast "Thyroid Talk with Dr. Angela Mazza" and serves on the faculty of the Metabolic Medical Institute and the Orlando College of Osteopathic Medicine. Dr. Mazza’s commitment to education, patient empowerment, and advancing endocrine care has earned her honors such as Greater Orlando’s Top Physician in Endocrinology and leadership roles on advisory boards and national planning committees. DOWNLOAD CV
PROGRAMS
Dr. Mazza presents a longevity-focused educational program that empowers individuals to take control of their health through evidence-based strategies. Integrating nutrition, movement, sleep, stress reduction, and metabolic support, the program guides participants in building daily habits that promote vitality and disease prevention.
By bridging science and holistic practices, the series empowers professionals and individuals alike to redefine health as a dynamic, resilient state of physical, mental, and emotional well-being. This professional correspondence program explores the meaning of true health through interviews with leading experts in integrative and functional self-care.
There is a direct link between disease prevention, longevity, and nutrition. Evidence shows that strategic dietary choices, targeted supplements, and protocols like intermittent fasting can optimize cellular health, reduce inflammation, and enhance metabolic function.
Modern analysis of aging reveals that we can age better by understanding and addressing both internal and external factors that accelerate decline. From environmental toxins to oxidative stress and inflammation, our bodies face constant pathological challenges.
Aesthetics play a vital role in longevity, influencing both psychological well-being and physical health. Feeling confident in one’s appearance can reduce stress, enhance self-esteem, and motivate healthier lifestyle habits.
Advanced testing and diagnostics offer critical insights into our health, helping to identify illness before symptoms arise. From blood panels and hormone profiles to genomic analysis and imaging scans, these tools uncover hidden imbalances and guide personalized care.
INNOVATIVE HEALTH - NEWSLETTER
More than a thyroid expert, Dr. Mazza is a visionary in proactive wellness. Her newsletter serves as a trusted guide for those looking to unlock their body’s potential, prevent chronic illness, and embrace a path of resilience, vitality, and meaningful longevity. The Road to Longevity is a new educational newsletter by Dr. Angela Mazza, a board-certified endocrinologist and expert in thyroid health. Building on the success of her acclaimed book Thyroid Talk, this publication explores the intricate connection between hormonal balance—especially thyroid function—and the pursuit of healthier aging. Dr. Mazza’s insights go beyond glandular disorders to examine how optimizing thyroid health can influence metabolism, energy, cognitive clarity, cardiovascular resilience, and overall vitality.
Each edition of The Road to Longevity dives deep into evidence-based strategies for extending healthspan, with articles addressing personalized nutrition, lifestyle interventions, stress management, and functional medicine approaches. Dr. Mazza brings a unique voice to the longevity conversation—one rooted in clinical science, yet deeply personal and passionate about helping individuals thrive as they age.
Dr. Angela Mazza is a highly recognized and sought-after public speaker, frequently featured in webinars, seminars, and health summits. Renowned for her expertise in thyroid health, she captivates audiences with her clarity, passion, and evidence-based insights—earning wide respect for making complex topics accessible and empowering to diverse audiences.
Thyroid Talk is Dr. Angela Mazza’s acclaimed podcast, featuring over 50 episodes covering groundbreaking topics in thyroid health, hormone balance, and longevity. With expert guests and practical insights, the show educates and empowers listeners to take control of their wellness journey through science-based strategies and real-world solutions for better living.
Dr. Angela Mazza is a nationally sought-after guest on top podcasts, talk shows, and wellness showcases. Known for her dynamic style and thyroid expertise, she delivers clear, impactful insights that engage audiences and inspire better health. Her voice is a trusted source in the evolving conversation on longevity and wellness.
APPEARANCES & EVENTS
Dr. Angela Mazza has recently returned from an inspiring series of national and international speaking engagements, solidifying her reputation as a sought-after voice in modern integrative medicine. As a board-certified endocrinologist with deep expertise in thyroid health, hormone balancing, diabetes care, and midlife women’s health, Dr. Mazza has become a leading figure in conversations around whole-body wellness and endocrine-driven longevity. She continues to be a featured expert across top-tier medical conferences, including the A4M (American Academy of Anti-Aging Medicine) national symposiums, the Institute for Functional Medicine (IFM) gatherings, and the prestigious Integrative Health Symposium (IHS) — where she captivates audiences with her ability to translate complex endocrine science into practical strategies for clinical care and preventive health.
Dr. Mazza’s presentations often center on the vital role hormones play in resilience, energy regulation, and disease prevention — with a particular focus on thyroid dysfunction, metabolic syndrome, and women’s midlife transitions. Her work bridges conventional endocrinology with cutting-edge functional medicine, offering a comprehensive and compassionate model of care. Whether speaking to fellow clinicians, health coaches, or wellness advocates, Dr. Mazza is widely recognized for her clarity, depth of knowledge, and passionate advocacy for patient-centered, hormone-informed healthcare.
Conferences & Expos
May 28-31, 2025
“Understand the Cortisol Connection: Dive into how stress impacts longevity through the lens of cortisol and adrenal function.”
Presented at 2025 IFM’s Functional Medicine Conference, San Diego, CA.
May 2-3, 2025
“All Things Thyroid and Patient Cases.”
Presented at 2025 Hormone Dosing Masterclass, Chicago, IL.
April 24-26, 2025
“Thyroid Disorders: A Metabolic Approach.”
Presented at 2025 A4M Spring Congress, Fellowship Module, West Palm Beach, FL.
March 13-15, 2025
“An Integrative Approach to Thyroid.”
Presented at 2025 A4M BHRT Symposium, San Antonio, TX.
Feb. 20-22, 2025
“Perspectives on Thyroid and Longevity.”
Presented at Integrative Health Symposium, New York City, NY.
Dec 13-15, 2024
“A Metabolic Approach to Thyroid Disorders.”
Presented at 2024 A4M LongevityFest, Las Vegas, CA.
Oct. 12 2024
“Navigating the Thyroid-Adrenal Connection & Its Effects on Mental Health.”
Presented at Integrative Medicine for Mental Health Conference, Washington DC, USA.
May 28-31, 2025: Dr. Mazza presents “Understand the Cortisol Connection: Dive into how stress impacts longevity through the lens of cortisol and adrenal function.” at the IFM 2025 AIC Conference. Also in this showcase is the exhibitors area with VIBRANT WELLNESS. Transforming Health Through Connection, Innovation, and Comprehensive Care. The 2025 AIC will explore diverse clinical topics, including therapeutic plasma exchange for autoimmune and neurological conditions, hypermobility and connective tissue disorders, peptide therapies, quantum biology, dietary approaches for longevity and well-being, wound care and pain management, personalized care and the gut microbiome, healthcare transformation, foundations of functional medicine, and other innovative subjects. [Click to see photo showcase 1 | Also check out Dr. Mazza's IFM 2025 Presentation]
Are you among the twenty million Americans feeling constantly exhausted, battling creeping weight gain, or wrestling with feelings of depression despite your best efforts? Do you find yourself reminiscing about those days of vitality, wishing you could revert back while simultaneously yearning to forge an ambitious, brighter future? If these challenges resonate with you or your patients, Thyroid Talk: An Integrative Endocrinologist’s Guide to Optimal Health by Dr. Mazza may just be the enlightening resource you've been seeking. Dr. Mazza, triple-board certified in Endocrinology, Internal Medicine, and Anti-Aging and Regenerative Medicine, goes beyond conventional medical “guidelines” and “standards of care.” She champions holistic health, tackles the thyroid epidemic directly, and envisions a future where doctors and patients collaborate seamlessly for optimal wellness and weight management.
WOMAN 2.0 – Personalized Strategies to Midlife (multi-author text)
Midlife is not a crisis—it's a transformation. In WOMAN 2.0: Personalized Strategies to Midlife Disorders, we reframe the conversation around women's health with science-driven insights, holistic therapies, and the voices of leading medical experts. This groundbreaking book unveils a new era of female empowerment through customized care, tackling the most pressing challenges of midlife including hormonal imbalances, metabolic shifts, cognitive fog, fatigue, and emotional burnout. Featuring contributions from trailblazers like Dr. Angela Mazza, a renowned endocrinologist and longevity advocate, and Dr. Roberta Kline, a pioneer in functional genomics and personalized medicine, WOMAN 2.0 delivers a roadmap to resilience. With additional essays from physicians, wellness coaches, and thought leaders in women’s health, this volume offers both clinical solutions and lifestyle strategies that honor the complexity of every woman’s body and journey. Your next chapter isn’t about survival—it’s about optimization. Welcome to WOMAN 2.0. The upgrade begins within.
Latest Video: Dr. Angela Mazza’s Holistic Vision for Endocrinology
In a packed Chicago conference room, Dr. Angela Mazza stood poised to challenge conventional thyroid treatment, advocating for a more integrative, patient-focused model of care. As a seasoned endocrinologist with a decade of functional practice, Dr. Mazza highlighted the thyroid’s central role in nearly every system of the body. She critiqued traditional reliance on TSH testing, warning that “labs alone don’t tell the full story” and must be aligned with clinical symptoms.
Mazza emphasized that 20-25% of patients have genetic polymorphisms hindering conversion of T4 to the active T3 hormone, leaving them symptomatic on standard T4 therapy. These patients often end up on statins, antidepressants, or blood pressure medications—without resolving their thyroid dysfunction. Her holistic approach combines micronutrient optimization, gut health, and personalized hormone strategies, including T3 and desiccated thyroid formulations. Encouragingly, she noted a slow shift within the American Thyroid Association toward individualized care. (See full podcast episode)
Photos by: https://www.nickmantzel.com/
